QXO (QXO) had the highest return between 2011 and 2015 by a large-cap US stock, returning 3,068,850%.

ASSET	YEARS	% RETURN
QXO (QXO)	2011-2015	3,068,850%
Regeneron Pharmaceuticals (REGN)	2011-2015	1,560.66%
Expedia (EXPE)	2011-2015	1,171.02%
Genmab A-S (GMAB)	2011-2015	892.74%
Alnylam Pharmaceuticals (ALNY)	2011-2015	849.95%
Tesla (TSLA)	2011-2015	794.19%
Manhattan Associates (MANH)	2011-2015	760.47%
Tyler Technologies (TYL)	2011-2015	732.47%
Domino's Pizza Inc Common Stock (DPZ)	2011-2015	675.19%
Neurocrine Biosciences (NBIX)	2011-2015	632.77%
Jazz Pharmaceuticals (JAZZ)	2011-2015	607.04%
Cheniere Energy (LNG)	2011-2015	562.82%
Incyte (INCY)	2011-2015	554.89%
Constellation Brands Inc Class A (STZ)	2011-2015	547.04%
Ionis Pharmaceuticals (IONS)	2011-2015	507.16%
DexCom (DXCM)	2011-2015	496.07%
EPAM Systems (EPAM)	2011-2015	471.78%
Monster Beverage (MNST)	2011-2015	465.85%
Gilead Sciences (GILD)	2011-2015	458.93%
Builders FirstSource (BLDR)	2011-2015	454%
Ulta Beauty (ULTA)	2011-2015	448.11%
Broadcom (AVGO)	2011-2015	447.39%
NetEase (NTES)	2011-2015	427.56%
Centene (CNC)	2011-2015	414.95%
Dycom Industries (DY)	2011-2015	369.22%

Large-cap stocks are treated as having a market cap of $10B+.