Natwest (NWG) had the highest return between 2004 and 2007 by a large-cap US stock, returning 15,058,300%.

ASSET	YEARS	% RETURN
Natwest (NWG)	2004-2007	15,058,300%
National Grid PLC ADR (NGG)	2004-2007	1,604,552.94%
Monster Beverage (MNST)	2004-2007	4,108.44%
Intuitive Surgical (ISRG)	2004-2007	1,788.89%
Apple (AAPL)	2004-2007	1,738.71%
Banco Bradesco SA ADR (BBD)	2004-2007	1,146.94%
First Solar (FSLR)	2004-2007	990.37%
Vale SA ADR (VALE)	2004-2007	941.22%
Suzano Papel e Celulose SA ADR (SUZ)	2004-2007	895.66%
CME (CME)	2004-2007	871.35%
ArcelorMittal SA ADR (MT)	2004-2007	866.45%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2004-2007	859.29%
Mosaic (MOS)	2004-2007	824.89%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2004-2007	808.67%
Illumina (ILMN)	2004-2007	711.78%
GameStop (GME)	2004-2007	686.19%
Hologic (HOLX)	2004-2007	684.91%
Elbit Systems (ESLT)	2004-2007	664.36%
Bancolombia SA ADR (CIB)	2004-2007	656.73%
Ambev SA ADR (ABEV)	2004-2007	648.87%
Tenaris SA ADR (TS)	2004-2007	643.41%
Deckers Outdoor (DECK)	2004-2007	628%
America Movil SAB de CV ADR (AMX)	2004-2007	622.19%
Alphabet Inc Class A (GOOGL)	2004-2007	591.43%
Trip Group Ltd ADR (TCOM)	2004-2007	588.11%

Large-cap stocks are treated as having a market cap of $10B+.