Natwest (NWG) had the highest return between 2007 and 2008 by a large-cap US stock, returning 1,589,066.7%.

ASSET	YEARS	% RETURN
Natwest (NWG)	2007-2008	1,589,066.67%
First Solar (FSLR)	2007-2008	357.28%
CF Industries (CF)	2007-2008	90.94%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2007-2008	82.42%
Stifel Financial (SF)	2007-2008	79.1%
Booking (BKNG)	2007-2008	67.46%
Mosaic (MOS)	2007-2008	60.4%
Gilead Sciences (GILD)	2007-2008	56.68%
Kinross Gold (KGC)	2007-2008	54.29%
McDonald’s (MCD)	2007-2008	50.42%
AeroVironment (AVAV)	2007-2008	47.24%
Aecom Technology (ACM)	2007-2008	45.64%
Mastercard (MA)	2007-2008	44.59%
Elbit Systems (ESLT)	2007-2008	42.21%
Royal Gold (RGLD)	2007-2008	39.51%
Teva Pharma Industries Ltd ADR (TEVA)	2007-2008	38.48%
Dollar Tree (DLTR)	2007-2008	37.35%
CH Robinson Worldwide (CHRW)	2007-2008	34.47%
Deckers Outdoor (DECK)	2007-2008	33.49%
Aon (AON)	2007-2008	33.21%
Illumina (ILMN)	2007-2008	32.71%
Amazon (AMZN)	2007-2008	32.57%
Church & Dwight (CHD)	2007-2008	32.11%
Intuitive Surgical (ISRG)	2007-2008	30.86%
Westinghouse Air Brake Technologies (WAB)	2007-2008	30.69%

Large-cap stocks are treated as having a market cap of $10B+.