InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2001 and 2004 by a large-cap US stock, returning 7,831,400%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2001-2004	7,831,400%
Eldorado Gold (EGO)	2001-2004	34,977.81%
First Majestic Silver (AG)	2001-2004	7,283.48%
Cheniere Energy (LNG)	2001-2004	2,576.37%
Tractor Supply (TSCO)	2001-2004	1,651.76%
NetEase (NTES)	2001-2004	1,593.03%
ArcelorMittal SA ADR (MT)	2001-2004	1,527.35%
Hecla Mining (HL)	2001-2004	936.46%
Darling Ingredients (DAR)	2001-2004	896.57%
Monster Beverage (MNST)	2001-2004	852.76%
Deckers Outdoor (DECK)	2001-2004	839.74%
Clean Harbors (CLH)	2001-2004	747.18%
Grupo Cibest (CIB)	2001-2004	706.68%
Tapestry (TPR)	2001-2004	688.13%
Old Dominion Freight Line (ODFL)	2001-2004	683.01%
Cognizant Technology Solutions Corp Class A (CTSH)	2001-2004	596.43%
eBay (EBAY)	2001-2004	590.7%
Cameco (CCJ)	2001-2004	544.65%
HF Sinclair (DINO)	2001-2004	543.68%
Royal Gold (RGLD)	2001-2004	540.93%
NVR (NVR)	2001-2004	522.49%
Genesis Healthcare (GEN)	2001-2004	503.89%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	2001-2004	498.71%
CME (CME)	2001-2004	497.24%
Centene (CNC)	2001-2004	495.99%

Large-cap stocks are treated as having a market cap of $10B+.