Booking (BKNG) had the highest return between 2006 and 2010 by a large-cap US stock, returning 1,690.1%.

ASSET	YEARS	% RETURN
Booking (BKNG)	2006-2010	1,690.1%
Baidu (BIDU)	2006-2010	1,402.41%
CF Industries (CF)	2006-2010	804.4%
Illumina (ILMN)	2006-2010	788.99%
Deckers Outdoor (DECK)	2006-2010	739.65%
Ambev SA ADR (ABEV)	2006-2010	650.3%
First Majestic Silver (AG)	2006-2010	558.51%
Wheaton Precious Metals (WPM)	2006-2010	552.84%
Netflix (NFLX)	2006-2010	549.42%
Southern Copper (SCCO)	2006-2010	503.38%
Credicorp (BAP)	2006-2010	501.6%
Mastercard (MA)	2006-2010	464.2%
Trip Group Ltd ADR (TCOM)	2006-2010	460.07%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2006-2010	436.22%
First Solar (FSLR)	2006-2010	431.18%
Cummins (CMI)	2006-2010	421.41%
Chipotle Mexican Grill (CMG)	2006-2010	372.58%
F5 Networks (FFIV)	2006-2010	351.08%
Apple (AAPL)	2006-2010	345.65%
Novo Nordisk A-S (NVO)	2006-2010	330.36%
Salesforce (CRM)	2006-2010	311.22%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	2006-2010	303.39%
Edwards Lifesciences (EW)	2006-2010	289.77%
Agnico Eagle Mines (AEM)	2006-2010	286.91%
Amazon (AMZN)	2006-2010	279.19%

Large-cap stocks are treated as having a market cap of $10B+.