Palantir Technologies (PLTR) had the highest return in April 2025 by a large-cap US stock, returning 41.2%.

ASSET	MONTH	% RETURN
Palantir Technologies (PLTR)	April 2025	41.18%
Sterling Construction (STRL)	April 2025	31.87%
MicroStrategy (MSTR)	April 2025	29.5%
Korea Electric Power Corp ADR (KEP)	April 2025	26.43%
Summit Therapeutics (SMMT)	April 2025	25.69%
CACI International (CACI)	April 2025	24.71%
Comfort Systems USA (FIX)	April 2025	24.06%
Rocket Lab USA (RKLB)	April 2025	23.18%
GameStop (GME)	April 2025	22.41%
Netflix (NFLX)	April 2025	22.02%
America Movil SAB de CV ADR (AMX)	April 2025	21.58%
Nu (NU)	April 2025	20.68%
GE Vernova LLC (GEV)	April 2025	20.64%
ServiceNow (NOW)	April 2025	19.64%
Crowdstrike (CRWD)	April 2025	19.48%
MercadoLibre (MELI)	April 2025	19.18%
Vertiv (VRT)	April 2025	18.73%
IES (IESC)	April 2025	18.59%
Cadence Design Systems (CDNS)	April 2025	17.85%
Axon Enterprise (AXON)	April 2025	17.58%
Robinhood Markets (HOOD)	April 2025	17.49%
Coinbase Global (COIN)	April 2025	17.4%
Amphenol (APH)	April 2025	17.36%
Carvana (CVNA)	April 2025	17.31%
Millicom International Cellular (TIGO)	April 2025	17.06%

Large-cap stocks are treated as having a market cap of $10B+.