NVIDIA (NVDA) had the highest return between 2011 and 2017 by a large-cap US stock in the Nasdaq Composite (IXIC), returning 1,245.1%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2011-2017	1,245.09%
Domino's Pizza Inc Common Stock (DPZ)	2011-2017	1,243.92%
Alnylam Pharmaceuticals (ALNY)	2011-2017	1,182.04%
Expedia (EXPE)	2011-2017	1,146.61%
Genmab A-S (GMAB)	2011-2017	1,127.85%
Tesla (TSLA)	2011-2017	1,059.98%
Regeneron Pharmaceuticals (REGN)	2011-2017	1,050.08%
Celsius (CELH)	2011-2017	1,041.55%
NetEase (NTES)	2011-2017	933.18%
Neurocrine Biosciences (NBIX)	2011-2017	905.05%
Broadcom (AVGO)	2011-2017	902.96%
Take-Two Interactive Software (TTWO)	2011-2017	791.07%
EXACT Sciences (EXAS)	2011-2017	767%
Charter Communications (CHTR)	2011-2017	759.67%
Netflix (NFLX)	2011-2017	667.84%
Monolithic Power Systems (MPWR)	2011-2017	640.54%
Monster Beverage (MNST)	2011-2017	621.25%
Diamondback Energy (FANG)	2011-2017	608.47%
Huazhu (HTHT)	2011-2017	574.61%
Ulta Beauty (ULTA)	2011-2017	562.65%
Amazon (AMZN)	2011-2017	544.8%
Manhattan Associates (MANH)	2011-2017	544.21%
Electronic Arts (EA)	2011-2017	536.73%
Pool (POOL)	2011-2017	532.82%
Cintas (CTAS)	2011-2017	515.18%

Large-cap stocks are treated as having a market cap of $10B+.