Praxis Precision Medicines (PRAX) had the highest return in Q4 2025 by a large-cap US stock, returning 458.9%.

ASSET	QUARTER	% RETURN
Praxis Precision Medicines (PRAX)	Q4 2025	458.85%
Lumentum (LITE)	Q4 2025	131.47%
Vicor (VICR)	Q4 2025	123.13%
Sandisk (SNDK)	Q4 2025	109.96%
Arrowhead Pharmaceuticals (ARWR)	Q4 2025	92.21%
Apogee Therapeutics, Inc Common Stock (APGE)	Q4 2025	90.8%
Coherent (COHR)	Q4 2025	75.75%
Albemarle (ALB)	Q4 2025	73.07%
Micron Technology (MU)	Q4 2025	72.53%
Revolution Medicines (RVMD)	Q4 2025	71.14%
Globalstar, Inc Common Stock (GSAT)	Q4 2025	69.79%
Tower Semiconductor (TSEM)	Q4 2025	63.51%
Guardant Health (GH)	Q4 2025	63.48%
Ciena (CIEN)	Q4 2025	62.14%
Alcoa (AA)	Q4 2025	61.46%
Abivax SA American Depositary Shares (ABVX)	Q4 2025	61.31%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	Q4 2025	57.94%
Hecla Mining (HL)	Q4 2025	57.08%
Teva Pharma Industries Ltd ADR (TEVA)	Q4 2025	54.89%
FormFactor (FORM)	Q4 2025	54.13%
Globus Medical (GMED)	Q4 2025	52.59%
Axsome Therapeutics (AXSM)	Q4 2025	49.11%
Enlight Renewable Energy Ltd Ordinary Shares (ENLT)	Q4 2025	48.9%
YPF Sociedad Anonima (YPF)	Q4 2025	47.71%
Warner Bros Discovery (WBD)	Q4 2025	47.57%

Large-cap stocks are treated as having a market cap of $10B+.