InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2003 and 2004 by a large-cap US stock, returning 7,863,100%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2003-2004	7,863,100%
Axon Enterprise (AXON)	2003-2004	9,277.78%
Chunghwa Telecom (CHT)	2003-2004	5,257.89%
Cheniere Energy (LNG)	2003-2004	4,800.39%
ArcelorMittal SA ADR (MT)	2003-2004	1,656.82%
Deckers Outdoor (DECK)	2003-2004	1,319.58%
Sirius XM (SIRI)	2003-2004	1,090.87%
Williams Companies (WMB)	2003-2004	996.28%
U-Haul (UHAL)	2003-2004	921.78%
Monster Beverage (MNST)	2003-2004	764.01%
Akamai Technologies (AKAM)	2003-2004	623.89%
Grupo Cibest (CIB)	2003-2004	568.79%
Arrowhead Pharmaceuticals (ARWR)	2003-2004	564.62%
CME (CME)	2003-2004	433.48%
WESCO International (WCC)	2003-2004	430.23%
Autodesk (ADSK)	2003-2004	428.76%
Wynn Resorts (WYNN)	2003-2004	414.38%
Insmed (INSM)	2003-2004	400%
Carpenter Technology (CRS)	2003-2004	380.35%
Vale SA ADR (VALE)	2003-2004	358.81%
YPF Sociedad Anonima (YPF)	2003-2004	357.15%
Mueller Industries (MLI)	2003-2004	354.9%
F5 Networks (FFIV)	2003-2004	353.21%
NetEase (NTES)	2003-2004	351.83%
Apple (AAPL)	2003-2004	348.53%

Large-cap stocks are treated as having a market cap of $10B+.