Monster Beverage (MNST) had the highest return between 2003 and 2006 by a large-cap US stock, returning 6,293.4%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2003-2006	6,293.39%
Cheniere Energy (LNG)	2003-2006	4,341.73%
Akamai Technologies (AKAM)	2003-2006	2,851.11%
Banco Bradesco SA ADR (BBD)	2003-2006	2,302.68%
Axon Enterprise (AXON)	2003-2006	2,154.81%
ArcelorMittal SA ADR (MT)	2003-2006	2,100.83%
U-Haul (UHAL)	2003-2006	1,857.28%
Williams Companies (WMB)	2003-2006	1,767.2%
Deckers Outdoor (DECK)	2003-2006	1,711.09%
Grupo Cibest (CIB)	2003-2006	1,496.32%
Allegheny Technologies (ATI)	2003-2006	1,493.67%
Tenaris SA ADR (TS)	2003-2006	1,365.44%
CME (CME)	2003-2006	1,104.15%
Apple (AAPL)	2003-2006	1,081.79%
Illumina (ILMN)	2003-2006	1,052.76%
Teck Resources Ltd Class B (TECK)	2003-2006	998.89%
Alamos Gold (AGI)	2003-2006	967.88%
WESCO International (WCC)	2003-2006	952.05%
Cameco (CCJ)	2003-2006	945.73%
Chunghwa Telecom (CHT)	2003-2006	922.26%
Southern Copper (SCCO)	2003-2006	912.66%
Vale SA ADR (VALE)	2003-2006	894.41%
America Movil SAB de CV ADR (AMX)	2003-2006	877.72%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2003-2006	805.5%
Itau Unibanco Banco (ITUB)	2003-2006	778.97%

Large-cap stocks are treated as having a market cap of $10B+.