Hudbay Minerals (HBM) had the highest return between 2006 and 2006 by a large-cap US stock, returning 260.4%.

ASSET	YEARS	% RETURN
Hudbay Minerals (HBM)	2006-2006	260.44%
Stonex (SNEX)	2006-2006	207.06%
Intercontinental Exchange (ICE)	2006-2006	195.62%
Riot Platforms (RIOT)	2006-2006	195%
Illumina (ILMN)	2006-2006	175.86%
Akamai Technologies (AKAM)	2006-2006	165.6%
Allegheny Technologies (ATI)	2006-2006	150.72%
Mastercard (MA)	2006-2006	144.71%
Las Vegas Sands (LVS)	2006-2006	125.28%
Align Technology (ALGN)	2006-2006	120%
Trip Group Ltd ADR (TCOM)	2006-2006	114.24%
Ambev SA ADR (ABEV)	2006-2006	113.06%
Deckers Outdoor (DECK)	2006-2006	110.42%
Ionis Pharmaceuticals (IONS)	2006-2006	110.21%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	2006-2006	107.43%
West Pharmaceutical Services (WST)	2006-2006	106.7%
Agnico Eagle Mines (AEM)	2006-2006	105.41%
Tenaris SA ADR (TS)	2006-2006	103.84%
NVIDIA (NVDA)	2006-2006	101.35%
Booking (BKNG)	2006-2006	95.39%
Suzano Papel e Celulose SA ADR (SUZ)	2006-2006	92.26%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	2006-2006	90.61%
IES (IESC)	2006-2006	89.24%
Albemarle (ALB)	2006-2006	88.63%
Credicorp (BAP)	2006-2006	88.45%

Large-cap stocks are treated as having a market cap of $10B+.