QXO (QXO) had the highest return between 2010 and 2013 by a large-cap US stock, returning 2,352,000%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2013	2,352,000%
Cheniere Energy (LNG)	2010-2013	1,624.79%
Jazz Pharmaceuticals (JAZZ)	2010-2013	1,470.22%
Regeneron Pharmaceuticals (REGN)	2010-2013	1,035.47%
Domino's Pizza Inc Common Stock (DPZ)	2010-2013	794.14%
Tesla (TSLA)	2010-2013	691.71%
United Rentals (URI)	2010-2013	685.78%
Expedia (EXPE)	2010-2013	594.03%
Netflix (NFLX)	2010-2013	563.17%
Tractor Supply (TSCO)	2010-2013	501.91%
Chipotle Mexican Grill (CMG)	2010-2013	494.62%
Las Vegas Sands (LVS)	2010-2013	462.11%
Dillard's (DDS)	2010-2013	458.04%
Incyte (INCY)	2010-2013	449.13%
Booking (BKNG)	2010-2013	422.85%
Biogen (BIIB)	2010-2013	418.01%
Tyler Technologies (TYL)	2010-2013	409.38%
Ulta Beauty (ULTA)	2010-2013	407.54%
XPO Logistics (XPO)	2010-2013	405.48%
U-Haul (UHAL)	2010-2013	397%
Manhattan Associates (MANH)	2010-2013	382.86%
LyondellBasell Industries (LYB)	2010-2013	380.22%
Corpay (CPAY)	2010-2013	368.68%
Constellation Brands Inc Class A (STZ)	2010-2013	339.33%
CoStar (CSGP)	2010-2013	335.54%

Large-cap stocks are treated as having a market cap of $10B+.