Carvana (CVNA) has had the highest return between 2023 and 2025 by a large-cap US stock, returning 6,242.4%.

ASSET	YEARS	% RETURN
Carvana (CVNA)	2023-2025	6,242.41%
Applovin (APP)	2023-2025	5,641.17%
Rigetti Computing (RGTI)	2023-2025	5,569.33%
IREN (IREN)	2023-2025	4,344.27%
Celestica (CLS)	2023-2025	2,904.68%
Palantir Technologies Inc Class A Common Stock (PLTR)	2023-2025	2,856.69%
D-Wave Quantum (QBTS)	2023-2025	2,307.33%
MicroStrategy (MSTR)	2023-2025	1,647.58%
IONQ (IONQ)	2023-2025	1,585.43%
Robinhood Markets (HOOD)	2023-2025	1,571.55%
Rocket Lab USA (RKLB)	2023-2025	1,482.34%
Ast Spacemobile (ASTS)	2023-2025	1,474.54%
Vertiv (VRT)	2023-2025	1,301.9%
Oklo (OKLO)	2023-2025	1,286.38%
NVIDIA (NVDA)	2023-2025	1,267.37%
Galaxy Digital (GLXY)	2023-2025	1,141.09%
Credo Technology (CRDO)	2023-2025	1,124.25%
Fortress Transp & Infra Inv (FTAI)	2023-2025	1,066.64%
Sterling Construction (STRL)	2023-2025	1,043.38%
Insmed (INSM)	2023-2025	865.31%
Coinbase Global (COIN)	2023-2025	800.27%
Carpenter Technology (CRS)	2023-2025	782.16%
Kratos Defense & Security Solutions (KTOS)	2023-2025	758.11%
Vistra Energy (VST)	2023-2025	751.37%
Comfort Systems USA (FIX)	2023-2025	742.29%

Large-cap stocks are treated as having a market cap of $10B+.