Celestica (CLS) has had the highest return between 2022 and 2025 by a large-cap US stock, returning 2,592.3%.

ASSET	YEARS	% RETURN
Celestica (CLS)	2022-2025	2,592.28%
Sterling Construction (STRL)	2022-2025	1,157.55%
Credo Technology (CRDO)	2022-2025	1,053.39%
Carpenter Technology (CRS)	2022-2025	1,049.57%
YPF Sociedad Anonima (YPF)	2022-2025	904.16%
Oklo (OKLO)	2022-2025	880.02%
Comfort Systems USA (FIX)	2022-2025	842.65%
Constellation Energy (CEG)	2022-2025	823.56%
Palantir Technologies (PLTR)	2022-2025	811.38%
Vistra Energy (VST)	2022-2025	722%
Super Micro Computer (SMCI)	2022-2025	682.34%
Insmed (INSM)	2022-2025	632.1%
TechnipFMC (FTI)	2022-2025	631.07%
Ast Spacemobile (ASTS)	2022-2025	625.94%
Fortress Transp & Infra Inv (FTAI)	2022-2025	617.54%
Flex (FLEX)	2022-2025	587.59%
Vertiv (VRT)	2022-2025	557.33%
Madrigal Pharmaceuticals (MDGL)	2022-2025	551.12%
Summit Therapeutics (SMMT)	2022-2025	548.78%
Howmet Aerospace (HWM)	2022-2025	536.58%
Robinhood Markets (HOOD)	2022-2025	533.24%
Allegheny Technologies (ATI)	2022-2025	512.86%
NVIDIA (NVDA)	2022-2025	509.43%
Applovin (APP)	2022-2025	453.69%
Broadcom (AVGO)	2022-2025	450.57%

Large-cap stocks are treated as having a market cap of $10B+.