Expedia (EXPE) had the highest return between 2004 and 2009 by a large-cap US stock, returning 6,264.8%.

ASSET	YEARS	% RETURN
Expedia (EXPE)	2004-2009	6,264.78%
Monster Beverage (MNST)	2004-2009	3,548.8%
Apple (AAPL)	2004-2009	1,856.06%
Intuitive Surgical (ISRG)	2004-2009	1,674.44%
Banco Bradesco SA ADR (BBD)	2004-2009	1,216.9%
Booking (BKNG)	2004-2009	1,110.13%
Grupo Cibest (CIB)	2004-2009	997.03%
Ambev SA ADR (ABEV)	2004-2009	949.77%
Vale SA ADR (VALE)	2004-2009	875.68%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2004-2009	806.79%
Elbit Systems (ESLT)	2004-2009	776.24%
Trip Group Ltd ADR (TCOM)	2004-2009	764.09%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2004-2009	752.69%
Illumina (ILMN)	2004-2009	740.55%
Suzano Papel e Celulose SA ADR (SUZ)	2004-2009	697.48%
Itau Unibanco Banco (ITUB)	2004-2009	689.53%
Tenaris SA ADR (TS)	2004-2009	645.74%
Credicorp (BAP)	2004-2009	602.15%
Clean Harbors (CLH)	2004-2009	570.53%
Southern Copper (SCCO)	2004-2009	553.17%
Mastercard (MA)	2004-2009	542.76%
ArcelorMittal SA ADR (MT)	2004-2009	533.93%
Baidu (BIDU)	2004-2009	523.08%
Stifel Financial (SF)	2004-2009	520.35%
Alphabet Inc Class A (GOOGL)	2004-2009	519.98%

Large-cap stocks are treated as having a market cap of $10B+.