Booking (BKNG) had the highest return between 2005 and 2009 by a large-cap US stock, returning 820.8%.

ASSET	YEARS	% RETURN
Booking (BKNG)	2005-2009	820.78%
Monster Beverage (MNST)	2005-2009	721.57%
Banco Bradesco SA ADR (BBD)	2005-2009	701.37%
Ambev SA ADR (ABEV)	2005-2009	700.73%
Intuitive Surgical (ISRG)	2005-2009	658.21%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2009	610.61%
Illumina (ILMN)	2005-2009	551.38%
Apple (AAPL)	2005-2009	550.63%
Mastercard (MA)	2005-2009	542.75%
Trip Group Ltd ADR (TCOM)	2005-2009	536.25%
Baidu (BIDU)	2005-2009	523.08%
Southern Copper (SCCO)	2005-2009	512.89%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2005-2009	472.89%
Credicorp (BAP)	2005-2009	471.71%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2005-2009	470.1%
CF Industries (CF)	2005-2009	468.44%
First Solar (FSLR)	2005-2009	452.65%
Wheaton Precious Metals (WPM)	2005-2009	409.16%
Tenaris SA ADR (TS)	2005-2009	387.9%
Vale SA ADR (VALE)	2005-2009	349.86%
Salesforce (CRM)	2005-2009	349.54%
Netflix (NFLX)	2005-2009	341.42%
Itau Unibanco Banco (ITUB)	2005-2009	332.26%
Western Digital (WDC)	2005-2009	304.67%
Agnico Eagle Mines (AEM)	2005-2009	301.03%

Large-cap stocks are treated as having a market cap of $10B+.