Advanced Micro Devices (AMD) had the highest return last month by a mega-cap US stock, returning 59.1%.

ASSET	MONTH	% RETURN
Advanced Micro Devices (AMD)	October 2025	59.15%
Micron Technology (MU)	October 2025	35.21%
Caterpillar (CAT)	October 2025	22.13%
Intuitive Surgical (ISRG)	October 2025	19.53%
Alphabet Inc Class A (GOOGL)	October 2025	16.8%
Thermo Fisher Scientific (TMO)	October 2025	16.51%
Eli Lilly and (LLY)	October 2025	13.04%
Broadcom (AVGO)	October 2025	12.64%
Amazon (AMZN)	October 2025	12.36%
Palantir Technologies (PLTR)	October 2025	10.56%
Salesforce (CRM)	October 2025	10.11%
ASML Holding NV ADR (ASML)	October 2025	9.89%
International Business Machines (IBM)	October 2025	9.71%
NVIDIA (NVDA)	October 2025	9.31%
American Express (AXP)	October 2025	9.26%
Cisco Systems (CSCO)	October 2025	8.32%
Taiwan Semiconductor Manufacturing (TSM)	October 2025	7.9%
Raytheon Technologies (RTX)	October 2025	7.61%
Toyota Motor Corporation ADR (TM)	October 2025	6.13%
Apple (AAPL)	October 2025	6.01%
Wells Fargo (WFC)	October 2025	4.66%
Morgan Stanley (MS)	October 2025	4.51%
GE Aerospace (GE)	October 2025	4.24%
Bank of America (BAC)	October 2025	4.19%
PepsiCo (PEP)	October 2025	3.75%

Mega-cap stocks are treated as having a market cap of $200B+.