NVIDIA (NVDA) had the highest return between 2019 and 2025 by a mega-cap US stock, returning 5,658.1%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2019-2025	5,658.13%
Tesla (TSLA)	2019-2025	2,103.79%
Palantir Technologies (PLTR)	2019-2025	1,677.5%
Broadcom (AVGO)	2019-2025	1,578.57%
Lam Research (LRCX)	2019-2025	1,306.43%
Advanced Micro Devices (AMD)	2019-2025	1,089.12%
Eli Lilly and (LLY)	2019-2025	928.83%
Taiwan Semiconductor Manufacturing (TSM)	2019-2025	877.92%
Micron Technology (MU)	2019-2025	843.61%
GE Aerospace (GE)	2019-2025	789.41%
Applied Materials (AMAT)	2019-2025	764.42%
ASML Holding NV ADR (ASML)	2019-2025	643.73%
Apple (AAPL)	2019-2025	638.38%
Goldman Sachs (GS)	2019-2025	529.61%
Alphabet Inc Class A (GOOGL)	2019-2025	514.03%
Morgan Stanley (MS)	2019-2025	465.7%
Caterpillar (CAT)	2019-2025	438.18%
Microsoft (MSFT)	2019-2025	419.82%
Facebook (META)	2019-2025	415.31%
GE Vernova LLC (GEV)	2019-2025	399.51%
Oracle (ORCL)	2019-2025	386.3%
Costco Wholesale (COST)	2019-2025	375.05%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2019-2025	337.69%
American Express (AXP)	2019-2025	332.78%
JPMorgan Chase (JPM)	2019-2025	308.62%

Mega-cap stocks are treated as having a market cap of $200B+.