INVO Fertility (IVF) had the highest return in Q4 2020 by a micro-cap US stock, returning 304,747.6%.

ASSET	QUARTER	% RETURN
INVO Fertility (IVF)	Q4 2020	304,747.64%
COSCIENS Biopharma (CSCI)	Q4 2020	4,697.32%
Ascent Solar Technologies, Inc Common Stock (ASTI)	Q4 2020	3,900%
urban-gro (UGRO)	Q4 2020	1,512.9%
Creative Medical Technology (CELZ)	Q4 2020	866.67%
Greenwich Lifesciences (GLSI)	Q4 2020	667.79%
Performance Shipping (PSHG)	Q4 2020	663.87%
Natuzzi SpA (NTZ)	Q4 2020	633.92%
Curis (CRIS)	Q4 2020	594.07%
Kaixin Auto (KXIN)	Q4 2020	563.7%
Beam Global (BEEM)	Q4 2020	486.95%
Ryvyl (RVYL)	Q4 2020	453.3%
Emeren (SOL)	Q4 2020	446.89%
Mega Matrix (MPU)	Q4 2020	445.61%
Bionano Genomics (BNGO)	Q4 2020	388.89%
Phoenix New Media (FENG)	Q4 2020	376.54%
Meiwu Technology (WNW)	Q4 2020	370.3%
Fuel Tech (FTEK)	Q4 2020	361.9%
ZEN Graphene Solutions (ZTEK)	Q4 2020	356.45%
Foresight Autonomous Holdings Ltd ADR (FRSX)	Q4 2020	343.48%
Zedge (ZDGE)	Q4 2020	325.04%
Aptevo Therapeutics (APVO)	Q4 2020	306.25%
SUI (SUIG)	Q4 2020	304.99%
Blink Charging (BLNK)	Q4 2020	301.03%
Versus Systems Inc. (VS)	Q4 2020	271.32%

Micro-cap stocks are treated as having a market cap of <= $300M.