Pharvaris (PHVS) had the highest return in December 2022 by a mid-cap US stock, returning 425.7%.

ASSET	MONTH	% RETURN
Pharvaris (PHVS)	December 2022	425.7%
Viking Therapeutics (VKTX)	December 2022	131.53%
Celcuity LLC (CELC)	December 2022	57.77%
Pulse Biosciences (PLSE)	December 2022	44.27%
Bilibili (BILI)	December 2022	42.2%
GDS (GDS)	December 2022	38.86%
Protagonist Therapeutics (PTGX)	December 2022	37.75%
SoundHound AI (SOUN)	December 2022	37.21%
NewAmsterdam Pharma Company NV Ordinary Shares (NAMS)	December 2022	37.11%
Perpetua Resources (PPTA)	December 2022	35.81%
Immunovant (IMVT)	December 2022	35.29%
Global Business Travel (GBTG)	December 2022	35%
TG Therapeutics (TGTX)	December 2022	33.22%
Powell Industries (POWL)	December 2022	32.8%
Leonardo DRS, Inc Common Stock (DRS)	December 2022	30.67%
Kingsoft Cloud Holdings (KC)	December 2022	28.09%
Vipshop (VIPS)	December 2022	27.6%
Liquidia Technologies (LQDA)	December 2022	26.14%
Embotelladora Andina (AKO.B)	December 2022	26.06%
New Oriental Education & Technology (EDU)	December 2022	25.84%
Arrowhead Pharmaceuticals (ARWR)	December 2022	25.53%
IAMGold (IAG)	December 2022	23.44%
Telecom Argentina SA ADR (TEO)	December 2022	23.02%
TAL Education (TAL)	December 2022	22.72%
Astronics (ATRO)	December 2022	22.18%

Mid-cap stocks are treated as having a market cap between $2B and $10B.