Rhythm Pharmaceuticals (RYTM) had the highest return on September 1, 2022 by a mid-cap US stock, returning 14.2%.

ASSET	DATE	% RETURN
Rhythm Pharmaceuticals (RYTM)	9/1/2022	14.2%
TMC the metals (TMC)	9/1/2022	13.82%
Belite Bio Inc ADR (BLTE)	9/1/2022	11.89%
DXC Technology (DXC)	9/1/2022	8.94%
CommScope (VISN)	9/1/2022	8.87%
SoundHound AI (SOUN)	9/1/2022	8.84%
Arcus Biosciences (RCUS)	9/1/2022	8.43%
Abercrombie & Fitch (ANF)	9/1/2022	8.35%
Dyne Therapeutics (DYN)	9/1/2022	7.86%
Amneal Pharmaceuticals, Inc Class A Common Stock (AMRX)	9/1/2022	7.83%
Lifestance Health (LFST)	9/1/2022	7.12%
Enel Chile SA ADR (ENIC)	9/1/2022	6.84%
Snap (SNAP)	9/1/2022	6.4%
Celcuity LLC (CELC)	9/1/2022	6.38%
Brinker International (EAT)	9/1/2022	6.21%
Protagonist Therapeutics (PTGX)	9/1/2022	6.13%
Tango Therapeutics (TNGX)	9/1/2022	5.97%
Arrowhead Pharmaceuticals (ARWR)	9/1/2022	5.47%
Apellis Pharmaceuticals (APLS)	9/1/2022	5.44%
Avadel Pharmaceuticals (AVDL)	9/1/2022	5.4%
Arcellx (ACLX)	9/1/2022	5.3%
Lemonade (LMND)	9/1/2022	5.15%
Global Business Travel (GBTG)	9/1/2022	4.94%
Travere Therapeutics (TVTX)	9/1/2022	4.9%
Praxis Precision Medicines (PRAX)	9/1/2022	4.84%

Mid-cap stocks are treated as having a market cap between $2B and $10B.