best performing mid cap stocks return in last 3 years

Soleno Therapeutics (SLNO) has had the highest return between December 18, 2022 and December 18, 2025 by a mid-cap US stock, returning 4,336.9%.

ASSETDATE% RETURN
Soleno Therapeutics (SLNO)
12/18/2022 - 12/18/2025
4,336.94%
QMMM Holdings Limited Ordinary Shares (QMMM)
12/18/2022 - 12/18/2025
3,880%
Rigetti Computing (RGTI)
12/18/2022 - 12/18/2025
2,369.23%
Cipher Mining (CIFR)
12/18/2022 - 12/18/2025
2,298.33%
Cidara Therapeutics (CDTX)
12/18/2022 - 12/18/2025
2,022.45%
Dave (DAVE)
12/18/2022 - 12/18/2025
1,963.95%
Regencell Bioscience (RGC)
12/18/2022 - 12/18/2025
1,927.99%
Terawulf (WULF)
12/18/2022 - 12/18/2025
1,766.13%
Sezzle (SEZL)
12/18/2022 - 12/18/2025
1,758.01%
GeneDx (WGS)
12/18/2022 - 12/18/2025
1,460.38%
IES (IESC)
12/18/2022 - 12/18/2025
1,308.42%
Olema Pharmaceuticals (OLMA)
12/18/2022 - 12/18/2025
1,275.53%
Applied Digital (APLD)
12/18/2022 - 12/18/2025
1,275%
Perpetua Resources (PPTA)
12/18/2022 - 12/18/2025
1,196.48%
D-Wave Quantum (QBTS)
12/18/2022 - 12/18/2025
996.77%
Eos Energy Enterprises (EOSE)
12/18/2022 - 12/18/2025
966.96%
Aura Minerals Inc Common Shares (AUGO)
12/18/2022 - 12/18/2025
920.49%
TMC the metals (TMC)
12/18/2022 - 12/18/2025
894.87%
SoundHound AI (SOUN)
12/18/2022 - 12/18/2025
872.57%
Abivax SA American Depositary Shares (ABVX)
12/18/2022 - 12/18/2025
855.34%
Protagonist Therapeutics (PTGX)
12/18/2022 - 12/18/2025
818.19%
Celcuity LLC (CELC)
12/18/2022 - 12/18/2025
815.43%
Sterling Construction (STRL)
12/18/2022 - 12/18/2025
808.59%
Powell Industries (POWL)
12/18/2022 - 12/18/2025
781.39%
New Gold (NGD)
12/18/2022 - 12/18/2025
773.26%
Mid-cap stocks are treated as having a market cap between $2B and $10B.