Azitra (AZTR) had the highest return in 2023 by a nano-cap US stock, returning 3,285,614.3%.

ASSET	YEAR	% RETURN
Azitra (AZTR)	2023	3,285,614.29%
Lottery (SEGG)	2023	11,791.18%
JIN MEDICAL INTERNATIONAL LTD Ordinary Shares (ZJYL)	2023	3,000.63%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2023	2,047.77%
Myomo (MYO)	2023	854.29%
Clean Energy Technologies, Inc Common Stock (CETY)	2023	703.43%
Direct Digital (DRCT)	2023	495.2%
Ebang International (EBON)	2023	415.15%
Applied Therapeutics (APLT)	2023	344.3%
Argo Blockchain PLC ADR (ARBK)	2023	311.44%
CASI Pharmaceuticals (CASI)	2023	306.82%
Minerva Neurosciences (NERV)	2023	284.38%
Tempest Therapeutics (TPST)	2023	269.75%
BIT Mining (BTCM)	2023	218.99%
Carbon Revolution Public Limited Ordinary Shares (CREV)	2023	203.88%
RDE (GIFT)	2023	182.69%
Sentage (SNTG)	2023	168.82%
Pintec Technology (PT)	2023	167.86%
BioLineRx (BLRX)	2023	161.67%
ICZOOM Group Inc Class A Ordinary Shares (IZM)	2023	160.75%
Fujian Blue Hat Interactive Entertainment Technology (BHAT)	2023	157.07%
Globus Maritime (GLBS)	2023	152.38%
Abits (ABTS)	2023	152.21%
ZK International (ZKIN)	2023	145%
Expion360 (XPON)	2023	136.4%

Nano-cap stocks are treated as having a market cap of <= $50M.