Regencell Bioscience (RGC) has had the highest return this year by a US stock in the Nasdaq Composite (IXIC), returning 17,040.7%.

ASSET	YEAR	% RETURN
Regencell Bioscience (RGC)	2025	17,040.72%
QMMM Holdings Limited Ordinary Shares (QMMM)	2025	9,155.81%
Abivax SA American Depositary Shares (ABVX)	2025	1,810.77%
Oncology Institute (TOI)	2025	1,092.81%
Hycroft Mining (HYMC)	2025	938.94%
XMax (XWIN)	2025	813.64%
Relmada Therapeutics (RLMD)	2025	773.17%
Palvella Therapeutics (PVLA)	2025	760.29%
Diginex Limited Ordinary Shares (DGNX)	2025	752.58%
Cidara Therapeutics (CDTX)	2025	714.46%
Abits (ABTS)	2025	693.1%
Aimei Health Technology Co, Ltd Ordinary Share (AFJK)	2025	675.4%
Celcuity LLC (CELC)	2025	655.82%
DeFi Development (DFDV)	2025	651.97%
Terns Pharmaceuticals (TERN)	2025	619.68%
AXT (AXTI)	2025	611.71%
Nanobiotix (NBTX)	2025	596.78%
Sandisk (SNDK)	2025	585.17%
Newegg Commerce (NEGG)	2025	557.5%
Rich Sparkle Holdings Limited Ordinary Shares (ANPA)	2025	555.56%
Charming Medical Limited Class A Ordinary Shares (MCTA)	2025	539.54%
Almonty Industries Inc Common Shares (ALM)	2025	517.36%
Lizhi (SOGP)	2025	505.79%
DBV Technologies (DBVT)	2025	483.89%
Anbio Biotechnology Class A Ordinary Shares (NNNN)	2025	470.15%