Advanced Micro Devices (AMD) had the highest return between 2016 and 2019 by a US stock in the S&P 500 (GSPC), returning 1,555.6%.

ASSET	YEARS	% RETURN
Advanced Micro Devices (AMD)	2016-2019	1,555.6%
Trade Desk (TTD)	2016-2019	803.58%
NVIDIA (NVDA)	2016-2019	643.57%
Paycom Soft (PAYC)	2016-2019	613.45%
Match (MTCH)	2016-2019	542.38%
Texas Pacific Land Trust (TPL)	2016-2019	534.18%
Block (XYZ)	2016-2019	390.67%
Copart (CPRT)	2016-2019	383.62%
Insulet (PODD)	2016-2019	360.22%
Lululemon Athletica (LULU)	2016-2019	331.33%
Axon Enterprise (AXON)	2016-2019	331.06%
Align Technology (ALGN)	2016-2019	329.36%
Apollo Global Management LLC Class A (APO)	2016-2019	315.01%
Lam Research (LRCX)	2016-2019	303.34%
Fair Isaac (FICO)	2016-2019	301.8%
Teledyne Technologies (TDY)	2016-2019	297.27%
TKO (TKO)	2016-2019	295.57%
Micron Technology (MU)	2016-2019	288.86%
ONEOK (OKE)	2016-2019	283.71%
MSCI (MSCI)	2016-2019	281.44%
Zebra Technologies (ZBRA)	2016-2019	277.42%
Amun Bitwise Select 10 Large Cap Crypto ETP (KEYS)	2016-2019	267.45%
Deckers Outdoor (DECK)	2016-2019	266.69%
IDEXX Laboratories (IDXX)	2016-2019	260.93%
CDW (CDW)	2016-2019	260.71%