Blackboxstocks (BLBX) had the highest return between 2015 and 2016 by a US stock, returning 17,400%.

ASSET	YEARS	% RETURN
Blackboxstocks (BLBX)	2015-2016	17,400%
Better Choice (BTTR)	2015-2016	5,528.57%
Ainos (AIMD)	2015-2016	4,636.84%
Creative Medical Technology (CELZ)	2015-2016	4,536.36%
Eastside Distilling (BLNE)	2015-2016	2,868.52%
Metalla Royalty & Streaming (MTA)	2015-2016	2,402.61%
Quoin Pharmaceuticals Ltd DRC (QNRX)	2015-2016	1,902.78%
GreenPro Capital (GRNQ)	2015-2016	1,528.57%
Datasea (DTSS)	2015-2016	1,390%
eXp World (EXPI)	2015-2016	1,272.25%
Nixxy (NIXX)	2015-2016	1,042.86%
Exelixis (EXEL)	2015-2016	914.29%
Biocardia (BCDA)	2015-2016	800.75%
Patriot National Bancorp (PNBK)	2015-2016	767.31%
Dolphin Entertainment (DLPN)	2015-2016	757.14%
LiveOne (LVO)	2015-2016	700%
Nocera (NCRA)	2015-2016	677.78%
Arena (AREN)	2015-2016	595.36%
FingerMotion (FNGR)	2015-2016	580%
Future Fintech (FTFT)	2015-2016	573.47%
Enveric Biosciences (ENVB)	2015-2016	572.19%
Theratechnologies (THTX)	2015-2016	570.97%
Ambow Education (AMBO)	2015-2016	566.67%
Cronos (CRON)	2015-2016	564.34%
EVI Industries (EVI)	2015-2016	457.5%