Applied Opt (AAOI) had the highest return between June 3, 2023 and June 3, 2025 and in 2023 by a small-cap US stock, returning 740%.
| ASSET | % RETURN |
|---|---|
Applied Opt (AAOI) | 740% |
Gyre Therapeutics (GYRE) | 585.07% |
Spyre Therapeutics (SYRE) | 537.63% |
ASP Isotopes Inc Common Stock (ASPI) | 364.94% |
Oncology Institute (TOI) | 353.33% |
LifeMD (LFMD) | 287.38% |
Eyepoint Pharmaceuticals (EYPT) | 287.1% |
Pharvaris (PHVS) | 224.28% |
Alpha Technology Group Limited Ordinary Shares (ATGL) | 217.5% |
Tango Therapeutics (TNGX) | 206.5% |
Ramaco Resources (METC) | 175.51% |
GigaCloud Technology Inc Class A Ordinary Shares (GCT) | 169.04% |
Altimmune (ALT) | 163.47% |
Olema Pharmaceuticals (OLMA) | 147.44% |
OppFi (OPFI) | 147.35% |
Bitfarms (BITF) | 146.61% |
Talkspace (TALK) | 146.6% |
Blend Labs (BLND) | 145.19% |
Alpha Metallurgical Resources (AMR) | 136.34% |
Tourmaline Bio (TRML) | 134.82% |
Akso Health Group ADR (AHG) | 131.25% |
Twist Bioscience (TWST) | 125.72% |
Taysha Gene Therapies (TSHA) | 123.48% |
Absci (ABSI) | 123.4% |
Porch (PRCH) | 123.19% |
Small-cap stocks are treated as having a market cap between $300M and $2B.
