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best performing stocks 21st century

Aptorum Group Ltd Class A (APM) has had the highest return since January 1, 2026 by a US stock, returning 764,445.5%.

ASSET% RETURN
Aptorum Group Ltd Class A (APM)
764,445.45%
Vyne Therapeutics (VYNE)
468,361.54%
WhiteHawk Minerals (WHK)
435,400%
Seaport Therapeutics, Inc Common Stock (SPTX)
243,900%
CBL International Limited Ordinary Shares (BANL)
2,223.75%
Lexaria Bioscience (LEXX)
1,565.86%
Trinity Biotech (TRIB)
1,294.51%
Mega Fortune Company Limited Ordinary Shares (MGRT)
1,273.63%
DarkIris Inc Class A Ordinary Shares (DKI)
1,180.91%
Adlai Nortye Ltd American Depositary Shares (ANL)
839.44%
Sandisk (SNDK)
631.27%
Aehr Test Systems (AEHR)
592.72%
Brand Engagement Network (BNAI)
542%
TEN Holdings, Inc Common Stock (XHLD)
503.28%
Roma Green Finance Limited Ordinary Shares (ROMA)
462.5%
AXT (AXTI)
457.97%
agilon health (AGL)
452.38%
Diana Shipping Inc WT (DSX.WT)
430.12%
Tenon Medical (TNON)
422.02%
Envirotech Vehicles (EVTV)
418.23%
Lianhe Sowell International Group Ltd Ordinary Shares (LHSW)
413.52%
AN2 Therapeutics (ANTX)
411.61%
Check-Cap (MBAI)
407.63%
Erasca (ERAS)
392.72%
Q32 Bio (QTTB)
383.33%

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