best performing stocks august 2025 to october 2025 mid or large cap

Uniqure (QURE) had the highest return between August 1, 2025 and October 31, 2025 by a US stock with a market cap of $2B+, returning 388%.

ASSETDATE% RETURN
Uniqure (QURE)
8/1/2025 - 10/31/2025
388.03%
Sandisk (SNDK)
8/1/2025 - 10/31/2025
372.57%
Bloom Energy (BE)
8/1/2025 - 10/31/2025
303.67%
AXT (AXTI)
8/1/2025 - 10/31/2025
297.5%
Opendoor Technologies (OPEN)
8/1/2025 - 10/31/2025
297.44%
IREN (IREN)
8/1/2025 - 10/31/2025
297.19%
Cipher Mining (CIFR)
8/1/2025 - 10/31/2025
270.63%
Praxis Precision Medicines  (PRAX)
8/1/2025 - 10/31/2025
269.44%
Keel Infrastructure (KEEL)
8/1/2025 - 10/31/2025
228.1%
Rigetti Computing (RGTI)
8/1/2025 - 10/31/2025
215.31%
Ondas (ONDS)
8/1/2025 - 10/31/2025
214.15%
Terawulf (WULF)
8/1/2025 - 10/31/2025
212.5%
Nektar Therapeutics (NKTR)
8/1/2025 - 10/31/2025
204.26%
Kodiak Sciences (KOD)
8/1/2025 - 10/31/2025
188.61%
Mineralys Therapeutics, Inc Common Stock (MLYS)
8/1/2025 - 10/31/2025
188.36%
GRAIL, LLC (GRAL)
8/1/2025 - 10/31/2025
180.53%
Applied Digital (APLD)
8/1/2025 - 10/31/2025
177.95%
Arrowhead Pharmaceuticals (ARWR)
8/1/2025 - 10/31/2025
173.48%
Lumen Technologies (LUMN)
8/1/2025 - 10/31/2025
155.72%
Hut 8 Corp Common Stock (HUT)
8/1/2025 - 10/31/2025
155.15%
ViaSat (VSAT)
8/1/2025 - 10/31/2025
151.87%
Nebius (NBIS)
8/1/2025 - 10/31/2025
151.72%
SharonAI Holdings, Inc Class A Common Stock (SHAZ)
8/1/2025 - 10/31/2025
148.57%
Precigen (PGEN)
8/1/2025 - 10/31/2025
147.9%
Energy Fuels (UUUU)
8/1/2025 - 10/31/2025
136.29%