Future Fintech (FTFT) had the highest return in the 2000s by a US stock, returning 13,183,900%.

ASSET	DECADE	% RETURN
Future Fintech (FTFT)	2000s	13,183,900%
InterContinental Hotels Group PLC ADR (IHG)	2000s	9,928,700%
Cemtrex (CETX)	2000s	4,938,903.31%
Northern Oil & Gas (NOG)	2000s	3,819,246.15%
India Globalization Capital (IGC)	2000s	2,299,900%
Houston American Energy (HUSA)	2000s	1,579,309.56%
Taoping (TAOP)	2000s	1,478,398.57%
National Grid PLC ADR (NGG)	2000s	1,161,476.47%
Know Labs (KNW)	2000s	1,068,548.85%
Hirequest (HQI)	2000s	935,500%
Natwest (NWG)	2000s	590,100%
Perspective Therapeutics (CATX)	2000s	296,566.67%
NextTrip (NTRP)	2000s	159,900%
Ring Energy (REI)	2000s	133,233.33%
Inseego (INSG)	2000s	132,733.33%
Ocean Power Technologies (OPTT)	2000s	100,011.11%
Gulf Resources (GURE)	2000s	58,200%
OPTIMIZERx (OPRX)	2000s	56,000%
Alto Ingredients (ALTO)	2000s	52,069.35%
Lixte Biotechnology (LIXT)	2000s	48,096.72%
Gyre Therapeutics (GYRE)	2000s	44,215.31%
ImmunoPrecise Antibodies (HYFT)	2000s	20,471.43%
TherapeuticsMD (TXMD)	2000s	19,503.88%
First Majestic Silver (AG)	2000s	17,180.89%
Enveric Biosciences (ENVB)	2000s	13,820.01%