Azitra (AZTR) had the highest return between 2016 and 2023 by a US stock, returning 3,285,614.3%.

ASSET	YEARS	% RETURN
Azitra (AZTR)	2016-2023	3,285,614.29%
MKDWELL Tech Inc Ordinary Share (MKDW)	2016-2023	2,812,400%
KULR Technology (KULR)	2016-2023	379,900%
Chijet Motor Company, Inc Ordinary Shares (CJET)	2016-2023	256,990.34%
Integra Resources (ITRG)	2016-2023	211,900%
Immatics (IMTX)	2016-2023	210,500%
BioNexus Gene Lab Corp Common stock (BGLC)	2016-2023	129,168.29%
Iqstel (IQST)	2016-2023	99,894.92%
MDxHealth SA ADR (MDXH)	2016-2023	93,709.52%
Lottery (SEGG)	2016-2023	55,432.79%
Heart Test Laboratories Inc Common Stock (HSCS)	2016-2023	50,194.12%
AquaBounty Technologies (AQB)	2016-2023	39,483.33%
Alarum Technologies (ALAR)	2016-2023	22,790.86%
Guardforce AI (GFAI)	2016-2023	15,861.54%
Aura Minerals Inc Common Shares (AUGO)	2016-2023	11,861.23%
ImmunoPrecise Antibodies (HYFT)	2016-2023	11,300%
Castellum (CTM)	2016-2023	10,937.04%
Connexa Sports Technologies (YYAI)	2016-2023	10,050%
DeFi Technologies (DEFT)	2016-2023	10,038%
Metalla Royalty & Streaming (MTA)	2016-2023	8,827.54%
Applied Digital (APLD)	2016-2023	8,541.03%
Celsius (CELH)	2016-2023	8,330.49%
Cybin (CYBN)	2016-2023	7,848.98%
VS Media Holdings Limited Class A Ordinary Shares (VSME)	2016-2023	7,311.76%
NVIDIA (NVDA)	2016-2023	6,184.21%