Jazz Pharmaceuticals (JAZZ) had the highest return between 2009 and 2011 by a large-cap US stock, returning 1,965.8%.

ASSET	YEARS	% RETURN
Jazz Pharmaceuticals (JAZZ)	2009-2011	1,965.78%
Onto Innovation (ONTO)	2009-2011	1,501.74%
Nova (NVMI)	2009-2011	1,240%
Lululemon Athletica (LULU)	2009-2011	1,073.84%
Dillard's (DDS)	2009-2011	1,070.88%
Baidu (BIDU)	2009-2011	782.35%
Ulta Beauty (ULTA)	2009-2011	681.22%
Somnigroup International (SGI)	2009-2011	661.29%
Teck Resources Ltd Class B (TECK)	2009-2011	631.43%
Las Vegas Sands (LVS)	2009-2011	624.23%
Domino's Pizza Inc Common Stock (DPZ)	2009-2011	619.28%
Cheniere Energy Partners (CQP)	2009-2011	562.05%
Booking (BKNG)	2009-2011	529.74%
Chipotle Mexican Grill (CMG)	2009-2011	445.71%
Williams-Sonoma (WSM)	2009-2011	426.57%
Starbucks (SBUX)	2009-2011	403.11%
MercadoLibre (MELI)	2009-2011	386.25%
Apple (AAPL)	2009-2011	371.6%
Ford Motor (F)	2009-2011	367.82%
F5 Networks (FFIV)	2009-2011	364.42%
Wheaton Precious Metals (WPM)	2009-2011	354.92%
Ambev SA ADR (ABEV)	2009-2011	353.81%
Tower Semiconductor (TSEM)	2009-2011	350%
TechnipFMC (FTI)	2009-2011	335.43%
Tenet Healthcare (THC)	2009-2011	334.75%

Large-cap stocks are treated as having a market cap of $10B+.