Carvana (CVNA) has had the highest return between 2023 and 2025 by a large-cap US stock, returning 7,201.5%.

ASSET	YEARS	% RETURN
Carvana (CVNA)	2023-2025	7,201.46%
Applovin (APP)	2023-2025	5,635.43%
Rigetti Computing (RGTI)	2023-2025	5,078.67%
IREN (IREN)	2023-2025	4,701.53%
Palantir Technologies Inc Class A Common Stock (PLTR)	2023-2025	2,705.93%
Celestica (CLS)	2023-2025	2,520.32%
D-Wave Quantum (QBTS)	2023-2025	2,076.67%
MicroStrategy (MSTR)	2023-2025	1,884.49%
Robinhood Markets (HOOD)	2023-2025	1,592.37%
IONQ (IONQ)	2023-2025	1,589.08%
Rocket Lab USA (RKLB)	2023-2025	1,576.88%
Ast Spacemobile (ASTS)	2023-2025	1,413.35%
Galaxy Digital (GLXY)	2023-2025	1,348%
Oklo (OKLO)	2023-2025	1,272.86%
Vertiv (VRT)	2023-2025	1,246.19%
NVIDIA (NVDA)	2023-2025	1,155.29%
Sterling Construction (STRL)	2023-2025	1,043.53%
Credo Technology (CRDO)	2023-2025	1,042.91%
Fortress Transp & Infra Inv (FTAI)	2023-2025	1,036.66%
Coinbase Global (COIN)	2023-2025	871.39%
Vistra Energy (VST)	2023-2025	804.15%
Kratos Defense & Security Solutions (KTOS)	2023-2025	786.1%
Carpenter Technology (CRS)	2023-2025	769.27%
Comfort Systems USA (FIX)	2023-2025	758.34%
Insmed (INSM)	2023-2025	693.54%

Large-cap stocks are treated as having a market cap of $10B+.