Apple (AAPL) had the highest return between 2009 and 2012 by a mega-cap US stock, returning 525.2%.

ASSET	YEARS	% RETURN
Apple (AAPL)	2009-2012	525.18%
Amazon (AMZN)	2009-2012	388.55%
ASML Holding NV New York Registry Shares (ASML)	2009-2012	247.7%
Mastercard (MA)	2009-2012	244.6%
American Express (AXP)	2009-2012	236.16%
Netflix (NFLX)	2009-2012	213.66%
Home Depot (HD)	2009-2012	202.26%
Visa Inc Class A (V)	2009-2012	194.87%
Amphenol (APH)	2009-2012	172.48%
Taiwan Semiconductor Manufacturing (TSM)	2009-2012	154.66%
KLA (KLAC)	2009-2012	147.19%
International Business Machines (IBM)	2009-2012	145.43%
SAP SE ADR (SAP)	2009-2012	142.1%
Royal Bank of Canada (RY)	2009-2012	140.62%
Micron Technology (MU)	2009-2012	139.25%
Alphabet Inc Class C (GOOG)	2009-2012	129.22%
Alphabet Inc Class A (GOOGL)	2009-2012	129.22%
Philip Morris International (PM)	2009-2012	127.3%
Caterpillar (CAT)	2009-2012	123.57%
Texas Instruments (TXN)	2009-2012	116.61%
Costco Wholesale (COST)	2009-2012	112.18%
UnitedHealth (UNH)	2009-2012	111.68%
BHP (BHP)	2009-2012	100%
LIN TV (LIN)	2009-2012	99.4%
Broadcom (AVGO)	2009-2012	98.15%

Mega-cap stocks are treated as having a market cap of $200B+.