Regencell Bioscience (RGC) has had the highest return this year by a US stock in the Nasdaq Composite (IXIC), returning 9,346.1%.

ASSET	YEAR	% RETURN
Regencell Bioscience (RGC)	2025	9,346.11%
QMMM Holdings Limited Ordinary Shares (QMMM)	2025	9,155.81%
Diginex Limited Ordinary Shares (DGNX)	2025	2,134.74%
Abivax SA American Depositary Shares (ABVX)	2025	1,597.51%
Oncology Institute (TOI)	2025	958.82%
DeFi Development (DFDV)	2025	906.09%
FiEE (FIEE)	2025	881.65%
Abits (ABTS)	2025	812.23%
Rich Sparkle Holdings Limited Ordinary Shares (ANPA)	2025	752.22%
Relmada Therapeutics (RLMD)	2025	732.69%
Cidara Therapeutics (CDTX)	2025	709.85%
Palvella Therapeutics (PVLA)	2025	688.46%
Newegg Commerce (NEGG)	2025	635.63%
Celcuity LLC (CELC)	2025	611.04%
Nanobiotix (NBTX)	2025	555.31%
Charming Medical Limited Class A Ordinary Shares (MCTA)	2025	539.54%
Sandisk (SNDK)	2025	458.93%
Global Interactive Technologies (GITS)	2025	443.57%
Inhibrx Biosciences (INBX)	2025	421.49%
JFB Construction Holdings Class A Common Stock (JFB)	2025	420.78%
Lizhi (SOGP)	2025	417.91%
Invivyd (IVVD)	2025	410.64%
Anbio Biotechnology Class A Ordinary Shares (NNNN)	2025	405.7%
Dominari (DOMH)	2025	386.06%
Better Home & Finance (BETR)	2025	383.34%