NVIDIA (NVDA) has had the highest return between 2019 and 2025 by a US stock in the S&P 500 (GSPC), returning 5,465.6%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2019-2025	5,465.57%
Super Micro Computer (SMCI)	2019-2025	3,707.11%
Tesla (TSLA)	2019-2025	2,051.12%
Palantir Technologies Inc Class A Common Stock (PLTR)	2019-2025	1,654.9%
Broadcom (AVGO)	2019-2025	1,547.28%
Axon Enterprise (AXON)	2019-2025	1,530.82%
Howmet Aerospace (HWM)	2019-2025	1,426.92%
Quanta Services (PWR)	2019-2025	1,315.54%
KLA-Tencor (KLAC)	2019-2025	1,299.33%
Advanced Micro Devices (AMD)	2019-2025	1,178.35%
EMCOR (EME)	2019-2025	1,059.22%
Lam Research (LRCX)	2019-2025	1,058.62%
Builders FirstSource (BLDR)	2019-2025	1,049.81%
Arista Networks (ANET)	2019-2025	1,044.12%
United Rentals (URI)	2019-2025	918.44%
Vistra Energy (VST)	2019-2025	863.68%
Constellation Energy (CEG)	2019-2025	851.61%
Monolithic Power Systems (MPWR)	2019-2025	833.46%
Williams-Sonoma (WSM)	2019-2025	779.62%
GE Aerospace (GE)	2019-2025	759.15%
Fair Isaac (FICO)	2019-2025	754.66%
Jabil Circuit (JBL)	2019-2025	751.87%
Applovin (APP)	2019-2025	706.89%
Crowdstrike (CRWD)	2019-2025	687.57%
Eli Lilly and (LLY)	2019-2025	676.63%