Cemtrex (CETX) had the highest return in the 2000s by a US stock, returning 4,938,903.3%.

ASSET	DECADE	% RETURN
Cemtrex (CETX)	2000s	4,938,903.31%
Northern Oil & Gas (NOG)	2000s	3,819,246.15%
India Globalization Capital (IGC)	2000s	2,299,900%
Houston American Energy (HUSA)	2000s	1,579,309.56%
Taoping (TAOP)	2000s	1,478,398.57%
Hirequest (HQI)	2000s	929,050%
Perspective Therapeutics (CATX)	2000s	296,566.67%
NextTrip (NTRP)	2000s	159,900%
Ring Energy (REI)	2000s	133,233.33%
Inseego (INSG)	2000s	132,733.33%
Ocean Power Technologies (OPTT)	2000s	100,011.11%
ProMIS Neurosciences (PMN)	2000s	77,002.8%
Alto Ingredients (ALTO)	2000s	52,069.35%
DeFi Technologies (DEFT)	2000s	42,500%
ImmunoPrecise Antibodies (HYFT)	2000s	20,471.43%
TherapeuticsMD (TXMD)	2000s	19,503.88%
Companhia Siderurgica Nacional ADR (SID)	2000s	12,673.16%
NanoViricides (NNVC)	2000s	11,800%
Broadwind Energy (BWEN)	2000s	9,608.39%
PharmaCyte Biotech (PMCB)	2000s	9,544.44%
MEDIFAST (MED)	2000s	8,793.12%
Monster Beverage (MNST)	2000s	7,074.89%
Americas Silver (USAS)	2000s	4,794.74%
Clean Harbors (CLH)	2000s	4,790.88%
Nixxy (NIXX)	2000s	4,342.67%