Protagenic Therapeutics (PTIXW) had the highest return in May 2025 by a US stock, returning 2,657.7%.

ASSET	MONTH	% RETURN
Protagenic Therapeutics (PTIXW)	May 2025	2,657.69%
Sharplink Gaming (SBET)	May 2025	2,267.28%
Regencell Bioscience (RGC)	May 2025	1,494.29%
Asset Entities Inc Class B Common Stock (ASST)	May 2025	1,082.52%
Kindly (NAKA)	May 2025	1,070.98%
NLS Pharmaceutics (NLSPW)	May 2025	866.67%
Next Technology (NXTT)	May 2025	516.13%
FiEE (FIEE)	May 2025	470.59%
M3-Brigade Acquisition V Corp Warrant (MBAVW)	May 2025	469.13%
DigiAsia (FAAS)	May 2025	465.72%
Streamex (STEX)	May 2025	438.46%
American Bitcoin (ABTC)	May 2025	415.02%
Edible Garden (EDBLW)	May 2025	359.33%
Dave Inc Warrants (DAVEW)	May 2025	345.02%
Siyata Mobile (SYTAW)	May 2025	299.4%
Nuvve (NVVEW)	May 2025	299.34%
Hyperscale Data (GPUS)	May 2025	291.24%
Roboai (AIIO)	May 2025	283.46%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	May 2025	281.25%
Medicus Pharma Ltd Warrant (MDCXW)	May 2025	277.81%
Spero Therapeutics (SPRO)	May 2025	273.13%
DigiAsia (FAASW)	May 2025	262.35%
Im Cannabis (IMCC)	May 2025	258.38%
CytomX Therapeutics (CTMX)	May 2025	258.11%
Pyxis Tankers (PXSAW)	May 2025	236.36%