Rhythm Pharmaceuticals (RYTM) had the highest return in August 2022 by a mid-cap US stock, returning 81.5%.

ASSET	MONTH	% RETURN
Rhythm Pharmaceuticals (RYTM)	August 2022	81.53%
Terns Pharmaceuticals (TERN)	August 2022	78.08%
Viridian Therapeutics (VRDN)	August 2022	70.06%
Axsome Therapeutics (AXSM)	August 2022	65.93%
Genius Sports (GENI)	August 2022	60.78%
Centrus Energy (LEU)	August 2022	51.58%
Immunome (IMNM)	August 2022	51.45%
Cogent Biosciences (COGT)	August 2022	48.56%
Fluence Energy (FLNC)	August 2022	47.78%
Globalstar, Inc Common Stock (GSAT)	August 2022	45.99%
PagSeguro Digital (PAGS)	August 2022	43.89%
Avadel Pharmaceuticals (AVDL)	August 2022	42.8%
Inter & Co Inc Class A Common Shares (INTR)	August 2022	42.67%
Applied Opt (AAOI)	August 2022	41.76%
Global-E Online (GLBE)	August 2022	40.34%
Zeta Global (ZETA)	August 2022	36.72%
Progyny (PGNY)	August 2022	33.94%
Plug Power (PLUG)	August 2022	32.95%
Catalyst Pharmaceuticals (CPRX)	August 2022	32.75%
Sonic Automotive (SAH)	August 2022	31.95%
TransMedics (TMDX)	August 2022	31.39%
Xometry (XMTR)	August 2022	30.59%
Vipshop (VIPS)	August 2022	29.87%
Kymera Therapeutics (KYMR)	August 2022	29.68%
Bausch Health Companies (BHC)	August 2022	29.22%

Mid-cap stocks are treated as having a market cap between $2B and $10B.