Yatsen (YSG) had the highest return in June 2022 by a small-cap US stock, returning 210.6%.

ASSET	MONTH	% RETURN
Yatsen (YSG)	June 2022	210.62%
Day One Biopharmaceuticals (DAWN)	June 2022	188.71%
Altimmune (ALT)	June 2022	134%
Mereo BioPharma Group PLC ADR (MREO)	June 2022	119.61%
Amylyx Pharmaceuticals (AMLX)	June 2022	114.24%
Entrada Therapeutics (TRDA)	June 2022	78.07%
DBV Technologies (DBVT)	June 2022	66.67%
Iovance Biotherapeutics (IOVA)	June 2022	66.02%
Lyell Immunopharma (LYEL)	June 2022	57.11%
Gaotu Techedu Inc DRC (GOTU)	June 2022	54.33%
UroGen Pharma (URGN)	June 2022	50.55%
Gyre Therapeutics (GYRE)	June 2022	44.72%
Allogene Therapeutics (ALLO)	June 2022	43.58%
Taysha Gene Therapies (TSHA)	June 2022	43.08%
Abcellera Biologics (ABCL)	June 2022	38.49%
Avalo Therapeutics (AVTX)	June 2022	37.74%
Kura Oncology (KURA)	June 2022	37.51%
Phreesia (PHR)	June 2022	35.92%
Envela (ELA)	June 2022	35.55%
Distribution Solutions (DSGR)	June 2022	33.48%
Oric Pharmaceuticals (ORIC)	June 2022	33.33%
Qudian (QD)	June 2022	32.63%
Kura Sushi USA (KRUS)	June 2022	30.45%
Semrush (SEMR)	June 2022	30.21%
I-Mab (IMAB)	June 2022	30.03%

Small-cap stocks are treated as having a market cap between $300M and $2B.