DeFi Development (DFDV) had the highest return in April 2025 by a small-cap US stock or small-cap US stock, returning 1,332.4%.

ASSET	MONTH	% RETURN
DeFi Development (DFDV)	April 2025	1,332.41%
ThredUp (TDUP)	April 2025	87.08%
Rezolve AI Limited Ordinary Shares (RZLV)	April 2025	83.33%
Hertz Global (HTZ)	April 2025	76.23%
SES AI (SES)	April 2025	74.56%
Forge Global (FRGE)	April 2025	72.5%
USA Rare Earth (USAR)	April 2025	72.01%
Nutex Health (NUTX)	April 2025	69.18%
American Battery Technology Company Common Stock (ABAT)	April 2025	66.02%
Forward Industries (FORD)	April 2025	65.04%
Lexicon Pharmaceuticals (LXRX)	April 2025	58.49%
Kodiak Sciences (KOD)	April 2025	56.27%
CorMedix (CRMD)	April 2025	51.15%
Canopy Growth (CGC)	April 2025	48.39%
Aardvark Therapeutics, Inc Common Stock (AARD)	April 2025	48.13%
Stoke Therapeutics (STOK)	April 2025	48.1%
Yalla Group (YALA)	April 2025	46.93%
Waton Financial Limited Ordinary Shares (WTF)	April 2025	46.85%
Amylyx Pharmaceuticals (AMLX)	April 2025	45.58%
United States Antimony (UAMY)	April 2025	45.25%
Compass Minerals International (CMP)	April 2025	44.67%
Upstream Bio (UPB)	April 2025	43.79%
Sellas Life Sciences (SLS)	April 2025	43.52%
MBX Biosciences, Inc Common Stock (MBX)	April 2025	43.5%
Keros Therapeutics (KROS)	April 2025	42.97%

Small-cap stocks are treated as having a market cap between $300M and $2B.