Praxis Precision Medicines (PRAX) had the highest return in October 2025 by a large-cap US stock, returning 276.9%.

ASSET	MONTH	% RETURN
Praxis Precision Medicines (PRAX)	October 2025	276.87%
Vicor (VICR)	October 2025	84.71%
Sandisk (SNDK)	October 2025	76.3%
Bloom Energy (BE)	October 2025	59.86%
Advanced Micro Devices (AMD)	October 2025	59.15%
Globalstar, Inc Common Stock (GSAT)	October 2025	51.35%
Symbotic (SYM)	October 2025	50.9%
Ast Spacemobile (ASTS)	October 2025	49.97%
Guardant Health (GH)	October 2025	48.88%
YPF Sociedad Anonima (YPF)	October 2025	48.82%
ASE Industrial Holding Co Ltd ADR (ASX)	October 2025	46.21%
Nokia (NOK)	October 2025	44.53%
Hut 8 Corp Common Stock (HUT)	October 2025	43.68%
Apogee Therapeutics, Inc Common Stock (APGE)	October 2025	43.05%
Celestica (CLS)	October 2025	42.67%
ViaSat (VSAT)	October 2025	42.42%
Applied Opt (AAOI)	October 2025	40.55%
Nextracker Inc Class A Common Stock (NXT)	October 2025	36.51%
Micron Technology (MU)	October 2025	35.21%
Qnity Electronics (Q)	October 2025	34.75%
Legence Corp Class A Common stock (LGN)	October 2025	34.27%
Teradyne (TER)	October 2025	33.73%
Twilio (TWLO)	October 2025	33.14%
Rocket Lab USA (RKLB)	October 2025	32.93%
Roivant Sciences (ROIV)	October 2025	32.12%

Large-cap stocks are treated as having a market cap of $10B+.