Praxis Precision Medicines (PRAX) had the highest return in October 2025 by a mid-cap US stock, returning 276.9%.

ASSET	MONTH	% RETURN
Praxis Precision Medicines (PRAX)	October 2025	276.87%
Grupo Financiero Galicia SA ADR (GGAL)	October 2025	114.08%
Banco Macro SA B ADR (BMA)	October 2025	109.29%
BBVA Banco Frances SA ADR (BBAR)	October 2025	93.54%
Central Puerto (CEPU)	October 2025	92.57%
Fluence Energy (FLNC)	October 2025	90.91%
Navitas Semiconductor (NVTS)	October 2025	88.78%
Vicor (VICR)	October 2025	84.71%
Dyne Therapeutics (DYN)	October 2025	77.8%
AXT (AXTI)	October 2025	77.06%
Lumen Technologies (LUMN)	October 2025	69.92%
Celcuity LLC (CELC)	October 2025	57.21%
GRAIL, LLC (GRAL)	October 2025	56.37%
Telecom Argentina SA ADR (TEO)	October 2025	56.03%
Immunovant (IMVT)	October 2025	53.1%
Rigetti Computing (RGTI)	October 2025	52.13%
D-Wave Quantum Inc Common Stock (QBTS)	October 2025	51.95%
FormFactor (FORM)	October 2025	51.84%
Applied Digital (APLD)	October 2025	51.82%
Travere Therapeutics (TVTX)	October 2025	51.42%
Transportadora de Gas del Sur SA ADR (TGS)	October 2025	48.45%
Liberty Energy (LBRT)	October 2025	47.48%
Oruka Therapeutics (ORKA)	October 2025	47.26%
Arcus Biosciences (RCUS)	October 2025	46.94%
Spyre Therapeutics (SYRE)	October 2025	46.2%

Mid-cap stocks are treated as having a market cap between $2B and $10B.