Sitio Royalties (STR) had the highest return between 2015 and 2021 by a US stock, returning 14,251,900%.

ASSET	YEARS	% RETURN
Sitio Royalties (STR)	2015-2021	14,251,900%
Chemomab Therapeutics Ltd DRC (CMMB)	2015-2021	13,799,900%
Amerant Bancorp (AMTB)	2015-2021	10,854,266.67%
Helport AI Limited Ordinary Shares (HPAI)	2015-2021	9,759,900%
BioNexus Gene Lab Corp Common stock (BGLC)	2015-2021	6,234,046.34%
KULR Technology (KULR)	2015-2021	5,519,900%
MDxHealth SA ADR (MDXH)	2015-2021	1,586,566.67%
Blackboxstocks (BLBX)	2015-2021	839,900%
MicroCloud Hologram (HOLO)	2015-2021	577,362.44%
Eastside Distilling (BLNE)	2015-2021	536,631.63%
Integra Resources (ITRG)	2015-2021	429,900%
Immatics (IMTX)	2015-2021	268,700%
FingerMotion (FNGR)	2015-2021	56,780%
Freedom (FRHC)	2015-2021	55,364%
Applied Digital (APLD)	2015-2021	43,095.88%
AquaBounty Technologies (AQB)	2015-2021	29,066.67%
eXp World (EXPI)	2015-2021	22,774.12%
Alarum Technologies (ALAR)	2015-2021	20,843.95%
Avalon GloboCare (ALBT)	2015-2021	17,471.43%
Celsius (CELH)	2015-2021	14,811.04%
HIVE Blockchain Technologies (HIVE)	2015-2021	12,471.43%
Kaival Brands Innovations (KAVL)	2015-2021	12,321.67%
Aura Minerals Inc Common Shares (AUGO)	2015-2021	11,618.79%
ABOT (ABOT)	2015-2021	11,308.51%
Metalla Royalty & Streaming (MTA)	2015-2021	9,878.58%