Klotho Neurosciences (KLTOW) had the highest return in June 2025 by a US stock, returning 1,056.9%.

ASSET	MONTH	% RETURN
Klotho Neurosciences (KLTOW)	June 2025	1,056.94%
Aeva Technologies, Inc Warrants (AEVAW)	June 2025	883.33%
Blue Gold Limited Warrant (BGLWW)	June 2025	850%
Vor Biopharma (VOR)	June 2025	710%
Klotho Neurosciences (KLTO)	June 2025	542.05%
Hyperion DeFi (HYPD)	June 2025	514.2%
mF International Limited Ordinary Shares (MFI)	June 2025	494.12%
Circle Internet (CRCL)	June 2025	484.81%
Citius Oncology (CTOR)	June 2025	383.33%
Genius (GNS)	June 2025	343%
Anbio Biotechnology Class A Ordinary Shares (NNNN)	June 2025	303.31%
Know Labs (KNW)	June 2025	296%
Prenetics (PRENW)	June 2025	294.95%
K Wave Media (KWMWW)	June 2025	290.29%
SBDS (SBDS)	June 2025	284.62%
Lizhi (SOGP)	June 2025	279.98%
So-Young International (SY)	June 2025	256.32%
Healthcare Triangle (HCTI)	June 2025	247.5%
Newegg Commerce (NEGG)	June 2025	234.85%
Pineapple Financial (PAPL)	June 2025	221.54%
UroGen Pharma (URGN)	June 2025	212.43%
Pheton Holdings Ltd Class A Ordinary Shares (PTHL)	June 2025	206.5%
TAO Synergies (TAOX)	June 2025	205.45%
Cyngn (CYN)	June 2025	195.69%
New Horizon Aircraft (HOVRW)	June 2025	177.81%