Cognizant Technology Solutions Corp Class A (CTSH) had the highest return between 1998 and 2003 by a large-cap US stock, returning 2,638.9%.

ASSET	YEARS	% RETURN
Cognizant Technology Solutions Corp Class A (CTSH)	1998-2003	2,638.86%
NVR (NVR)	1998-2003	2,030.29%
eBay (EBAY)	1998-2003	1,349.19%
Axon Enterprise (AXON)	1998-2003	1,076.79%
Tractor Supply (TSCO)	1998-2003	994.85%
Amazon (AMZN)	1998-2003	952.4%
Qualcomm (QCOM)	1998-2003	786.06%
Pool (POOL)	1998-2003	782.35%
Quest Diagnostics (DGX)	1998-2003	766.48%
Best Buy (BBY)	1998-2003	752.98%
Laboratory Corporation of America (LH)	1998-2003	744.76%
Ryanair Holdings PLC ADR (RYAAY)	1998-2003	710.52%
Tapestry (TPR)	1998-2003	655.03%
Neurocrine Biosciences (NBIX)	1998-2003	581.75%
Biogen (BIIB)	1998-2003	540.58%
Genesis Healthcare (GEN)	1998-2003	523.72%
Gilead Sciences (GILD)	1998-2003	509.47%
ResMed (RMD)	1998-2003	488.19%
Copart (CPRT)	1998-2003	477.78%
Logitech International (LOGI)	1998-2003	471.82%
ANSYS (ANSS)	1998-2003	467.14%
Take-Two Interactive Software (TTWO)	1998-2003	462.35%
East West Bancorp (EWBC)	1998-2003	460.84%
Infosys Ltd ADR (INFY)	1998-2003	455.16%
AngloGold Ashanti (AU)	1998-2003	447.6%

Large-cap stocks are treated as having a market cap of $10B+.