AngloGold Ashanti (AU) had the highest return between 1998 and 2003 by a large-cap US stock, returning 18,198,850%.

ASSET	YEARS	% RETURN
AngloGold Ashanti (AU)	1998-2003	18,198,850%
Cognizant Technology Solutions Corp Class A (CTSH)	1998-2003	2,637.87%
NVR (NVR)	1998-2003	2,030.29%
eBay (EBAY)	1998-2003	1,349.13%
Ovintiv (OVV)	1998-2003	1,010.03%
Tractor Supply (TSCO)	1998-2003	994.07%
Amazon (AMZN)	1998-2003	952.4%
Hudbay Minerals (HBM)	1998-2003	825.08%
Oshkosh (OSK)	1998-2003	795.8%
Qualcomm (QCOM)	1998-2003	786.03%
Quest Diagnostics (DGX)	1998-2003	766.49%
Best Buy (BBY)	1998-2003	752.97%
Laboratory Corporation of America (LH)	1998-2003	744.74%
Harmony Gold Mining (HMY)	1998-2003	735.23%
Ryanair Holdings PLC ADR (RYAAY)	1998-2003	710.53%
Tapestry (TPR)	1998-2003	655.01%
Neurocrine Biosciences (NBIX)	1998-2003	581.75%
Biogen (BIIB)	1998-2003	540.58%
Genesis Healthcare (GEN)	1998-2003	523.7%
Gilead Sciences (GILD)	1998-2003	509.5%
Chunghwa Telecom (CHT)	1998-2003	501.4%
Johnson Controls International (JCI)	1998-2003	498.16%
ResMed (RMD)	1998-2003	488.21%
Copart (CPRT)	1998-2003	477.78%
Logitech International (LOGI)	1998-2003	471.86%

Large-cap stocks are treated as having a market cap of $10B+.