Applied Digital (APLD) has had the highest return this decade by a US stock, returning 3,172,400%.

ASSET	DECADE	% RETURN
Applied Digital (APLD)	2020s	3,172,400%
Integra Resources (ITRG)	2020s	689,900%
MDxHealth SA ADR (MDXH)	2020s	323,536.36%
DevvStream Corp Common Stock (DEVS)	2020s	104,900%
BioNexus Gene Lab Corp Common stock (BGLC)	2020s	64,534.15%
COSCIENS Biopharma (CSCI)	2020s	34,306.78%
MKDWELL Tech Inc Ordinary Share (MKDW)	2020s	25,525%
Castellum (CTM)	2020s	16,990.91%
Heart Test Laboratories Inc Common Stock (HSCS)	2020s	9,723.53%
Regencell Bioscience (RGC)	2020s	8,733.12%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2020s	6,365.26%
Innodata (INOD)	2020s	5,501.75%
Azitra (AZTR)	2020s	4,630.36%
VS Media Holdings Limited Class A Ordinary Shares (VSME)	2020s	4,549.86%
Centrus Energy (LEU)	2020s	4,282.27%
IsoEnergy (ISOU)	2020s	4,175.29%
Lottery (SEGG)	2020s	3,968.44%
QMMM Holdings Limited Ordinary Shares (QMMM)	2020s	3,880%
Galaxy Digital (GLXY)	2020s	3,594.66%
Celestica (CLS)	2020s	3,510.11%
Cybin (CYBN)	2020s	3,356.63%
Celsius (CELH)	2020s	3,214.91%
DeFi Technologies (DEFT)	2020s	3,185.71%
NVIDIA (NVDA)	2020s	3,139.71%
Santech (STEC)	2020s	2,934.67%