P10 (PX) has had the highest return this decade by a US stock, returning 10,749,900%.

ASSET	DECADE	% RETURN
P10 (PX)	2020s	10,749,900%
Brera Holdings PLC Class B Ordinary Shares (BREA)	2020s	1,537,900%
Diversified Energy (DEC)	2020s	555,669.23%
BioNexus Gene Lab Corp Common stock (BGLC)	2020s	156,729.27%
Applied Digital (APLD)	2020s	24,089.81%
CID HoldCo, Inc Warrants (DAICW)	2020s	19,575%
Wearable Devices (WLDSW)	2020s	10,069.49%
Regencell Bioscience (RGC)	2020s	7,179.92%
Sezzle Inc Common Stock (SEZL)	2020s	4,725.43%
Azitra (AZTR)	2020s	4,382.14%
Innodata (INOD)	2020s	4,297.37%
Limbach (LMB)	2020s	3,910.75%
Celsius (CELH)	2020s	2,791.93%
MicroStrategy (MSTR)	2020s	2,728.27%
CPI Card (PMTS)	2020s	2,690%
Indivior PLC Ordinary Shares (INDV)	2020s	2,632.27%
NVIDIA (NVDA)	2020s	2,581%
Centrus Energy (LEU)	2020s	2,453.05%
IsoEnergy (ISOU)	2020s	2,218.41%
HCM II Acquisition (HONDW)	2020s	2,185.71%
Trump Media & Technology (DJTWW)	2020s	2,021.43%
Super Micro Computer (SMCI)	2020s	1,936.06%
Build-A-Bear Workshop (BBW)	2020s	1,844.82%
Celestica (CLS)	2020s	1,816.49%
LifeMD (LFMD)	2020s	1,685.71%