Biohaven Pharmaceutical (BHVN) had the highest return in October 2022 by a small-cap US stock, returning 159.3%.

ASSET	MONTH	% RETURN
Biohaven Pharmaceutical (BHVN)	October 2022	159.31%
Sellas Life Sciences (SLS)	October 2022	134%
Tango Therapeutics (TNGX)	October 2022	117.3%
Enliven Therapeutics (ELVN)	October 2022	92.21%
SS Innovations International Inc Common Stock (SSII)	October 2022	84.09%
Helix Energy Solutions (HLX)	October 2022	71.99%
TROOPS (TROO)	October 2022	63.79%
Monopar Therapeutics (MNPR)	October 2022	60.78%
Nabors Industries (NBR)	October 2022	60.65%
Cooper Stnd (CPS)	October 2022	58.33%
Oil States International (OIS)	October 2022	57.8%
RPC (RES)	October 2022	51.43%
Novonix Ltd ADR (NVX)	October 2022	50.21%
Calumet Specialty Products Partners (CLMT)	October 2022	48.47%
Tilray (TLRY)	October 2022	45.88%
Riley Exploration Permian (REPX)	October 2022	45.71%
Byrna Technologies (BYRN)	October 2022	45.47%
Ardmore Shpng (ASC)	October 2022	44.4%
Entrada Therapeutics (TRDA)	October 2022	43.97%
Aehr Test Systems (AEHR)	October 2022	43.65%
Pacific Biosciences of California (PACB)	October 2022	43.05%
Greenbrier Companies (GBX)	October 2022	42.84%
Citi Trends (CTRN)	October 2022	41.93%
Sylvamo (SLVM)	October 2022	41.64%
Rayonier Advanced Materials (RYAM)	October 2022	40.87%

Small-cap stocks are treated as having a market cap between $300M and $2B.