Seanergy Maritime (SHIP) had the highest return in 2008 by a small-cap US stock, returning 10,527,832.6%.

ASSET	YEAR	% RETURN
Seanergy Maritime (SHIP)	2008	10,527,832.62%
Oxley Bridge Acquisition Limited Class A Ordinary Shares (OBA)	2008	5,749.06%
Emergent Biosolutions (EBS)	2008	421.16%
MiMedx (MDXG)	2008	339.96%
Lineage Cell Therapeutics (LCTX)	2008	331.75%
Crawford (CRD.B)	2008	251.21%
Metalla Royalty & Streaming (MTA)	2008	171.43%
Crawford (CRD.A)	2008	87.74%
Altimmune (ALT)	2008	75%
Republic Bancorp (RBCAA)	2008	69.56%
Onity (ONIT)	2008	66.3%
Vaalco Energy (EGY)	2008	60%
National Presto Industries (NPK)	2008	58.16%
Univest Corporation Pennsylvania (UVSP)	2008	57.28%
Capitol Federal Financial (CFFN)	2008	54.81%
Tompkins Financial (TMP)	2008	53.7%
Allegiant Travel (ALGT)	2008	51.45%
First Financial Corporation Indiana (THFF)	2008	48.01%
Stepan (SCL)	2008	47.48%
Compass Minerals International (CMP)	2008	46.25%
Myriad Genetics (MYGN)	2008	44.04%
Ituran Location and Control (ITRN)	2008	40.74%
1st Source (SRCE)	2008	39.48%
Community Trust Bancorp (CTBI)	2008	38.53%
Burke & Herbert Financial Services Corp Common Stock (BHRB)	2008	36.41%

Small-cap stocks are treated as having a market cap between $300M and $2B.