Booking (BKNG) had the highest return between 1999 and 2008 by a US stock, returning 24,154,666.7%.

ASSET	YEARS	% RETURN
Booking (BKNG)	1999-2008	24,154,666.67%
India Globalization Capital (IGC)	1999-2008	1,616,566.67%
Hirequest (HQI)	1999-2008	929,050%
Taoping (TAOP)	1999-2008	863,957.6%
Houston American Energy (HUSA)	1999-2008	853,743.24%
Northern Oil & Gas (NOG)	1999-2008	838,607.69%
Cemtrex (CETX)	1999-2008	389,915.48%
NextTrip (NTRP)	1999-2008	159,900%
Ring Energy (REI)	1999-2008	146,566.67%
Inseego (INSG)	1999-2008	77,233.33%
Ocean Power Technologies (OPTT)	1999-2008	74,233.33%
Perspective Therapeutics (CATX)	1999-2008	66,566.67%
ProMIS Neurosciences (PMN)	1999-2008	64,385.98%
Flexible Solutions International (FSI)	1999-2008	37,464.71%
Alto Ingredients (ALTO)	1999-2008	31,587.24%
Frontline (FRO)	1999-2008	19,305.16%
PharmaCyte Biotech (PMCB)	1999-2008	12,988.89%
NanoViricides (NNVC)	1999-2008	11,240%
Companhia Siderurgica Nacional ADR (SID)	1999-2008	7,801.09%
TherapeuticsMD (TXMD)	1999-2008	7,439.95%
Broadwind Energy (BWEN)	1999-2008	5,300.22%
Monster Beverage (MNST)	1999-2008	4,898.57%
MiMedx (MDXG)	1999-2008	4,300%
ImmunoPrecise Antibodies (HYFT)	1999-2008	4,185.71%
Clean Harbors (CLH)	1999-2008	3,804%